For Sale
Single family home for sale at 422 21st Street, Denver, CO 80205 | MLS# 6487194 | Listing updated on 2026-08-24
Photo 1 of Single family home for sale at 422 21st Street, Denver, CO 80205 | MLS# 6487194 | Listing updated on 2026-08-24
Photo 2 of Single family home for sale at 422 21st Street, Denver, CO 80205 | MLS# 6487194 | Listing updated on 2026-08-24
Photo 3 of Single family home for sale at 422 21st Street, Denver, CO 80205 | MLS# 6487194 | Listing updated on 2026-08-24
Photo 4 of Single family home for sale at 422 21st Street, Denver, CO 80205 | MLS# 6487194 | Listing updated on 2026-08-24
30+
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Street View

$1,000,000

Monthly Est:$4,977

  • Beds Icon4 Beds
  • Beds Icon
    2 Baths
  • Beds Icon2,565sqft

422 21st Street, Denver, CO 80205

$4,977/moEst:

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  • Single Family Residence

  • Built in 1886

  • $-- HOA

  • 6,270 sqft lot

  • $390/sq.ft

Description

Rare and storied mixed-use opportunity situated on a highly visible 6,270-square-foot corner lot in the heart of Five Points. The property features a historic five-bedroom residence and a separate office building, totaling approximately 6,565 square feet of improvements on a single parcel. Ideally positioned just steps from Benedict Fountain Park, the RTD 27th & Welton Light Rail Station, neighborhood coffee shops and restaurants, and only minutes from Downtown Denver and Uptown, the property offers an exceptional blend of urban convenience, historic character, and neighborhood connectivity. The property includes an approximately 2,565-square-foot historic residence with five bedrooms and two bathrooms, currently operating as a successful Airbnb and providing immediate income or the opportunity for owner occupancy. Tucked behind the residence is a rare, private rear
patio, offering an inviting outdoor retreat ideal for entertaining, relaxing, or complementing a live/work lifestyle—an uncommon amenity for a property so close to downtown. Complementing the residence is a separate office duplex totaling approximately 4,000 square feet, comprised of two approximately 2,000-square-foot office suites, one of which is currently leased on a month-to-month basis, providing immediate cash flow while preserving flexibility for future occupancy, repositioning, or redevelopment.
Located within the Clements Historic District, this unique property offers exceptional visibility, walkability, and access to some of Denver’s most desirable dining, entertainment, cultural, and transit amenities. Whether envisioned as an investment, corporate headquarters with supplemental income, creative office campus, live/work environment, boutique hospitality concept, or long-term repositioning opportunity, this one-of-a-kind asset presents remarkable versatility in one of Denver’s most vibrant and historically significant neighborhoods.

  • Houzeo last checked: 12 hours ago
  • Listing updated: August 24, 2026 at 3:12 pm
  • Listing Provided by: Karen Zeile (303) 947-3665 | Kentwood Commercial, Llc (303) 773-3399
  • Source: DENVER (RE COLORADO) MLS-CO | MLS#: 6487194 DENVER (RE COLORADO) MLS-CO

Property Details

  • Status

    Active

  • Type

    Single Family Residence

  • No. of Stories

    -

  • County

    Denver County

  • City

    Denver

  • Neighborhood

    Five Points

  • Year Built

    1886

  • HOA Fees

    -

  • Finished Area

    2,565 sqft

  • Lot Size

    6,270 sqft lot

  • Basement Area

    - sqft

  • MLS Name

    DENVER (RE COLORADO) MLS

  • MLS Number

    6487194

  • MLS Status

    Active

  • Days on Market

    241

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Location

Facts & Features

Rooms

  • Bedrooms & bathrooms

    Bedrooms: 4

    Bathrooms: 2

  • Bathroom Full

    Level: Upper

  • Bathroom Three Quarter

    Level: Main

  • Bedroom

    Level: Main

  • Bedroom

    Level: Upper

  • Bedroom

    Level: Upper

  • Bedroom

    Level: Upper

Interior

  • Sewer

    Public Sewer

  • Cooling

    None

  • Heating

    Hot Water

Construction

  • Year Built

    Year Built: 1886

  • Home type

    Single Family Residence

  • Roof

    Composition

  • Construction Materials

    Brick

Other Features

  • Subdivision Name

    Five Points

  • Lot Features

    Level

Price History

DateEventPrice

08/24/2026

Source: #REC6487194

Price Decreased

$1,000,000 -9.09%

$390/sqft

07/24/2026

Source: mls_logoDENVER (RE COLORADO) MLS-CO #REC6487194

Price Decreased

$1,100,000 -4.35%

$429/sqft

06/24/2026

Source: mls_logoDENVER (RE COLORADO) MLS-CO #REC6487194

Listed for Sale

$1,150,000

$448/sqft

06/24/2026

Source: mls_logoDENVER (RE COLORADO) MLS-CO #REC6487194

Price Decreased

$1,150,000 -4.17%

$448/sqft

03/27/2026

Source: mls_logoDENVER (RE COLORADO) MLS-CO #REC6487194

Pending

$1,200,000

$468/sqft

Show more

Five Points Ranks #5 in Denver, CO

Homes for sale
135

Homes

Rental prices
$1,998

Rental Prices

Median Home Price
$442.5K

Median Home Price

Five Points, Denver, CO neighborhood guide

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