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Street View
$1,000,000
Monthly Est:$4,977
4 Beds
- 2 Baths
1 full bath
2,565sqft
422 21st Street, Denver, CO 80205
$1,000,000
$4,977/moEst:
Get Pre-Approved
Single Family Residence
Built in 1886
$-- HOA
6,270 sqft lot
$390/sq.ft
Description
Rare and storied mixed-use opportunity situated on a highly visible 6,270-square-foot corner lot in the heart of Five Points. The property features a historic five-bedroom residence and a separate office building, totaling approximately 6,565 square feet of improvements on a single parcel. Ideally positioned just steps from Benedict Fountain Park, the RTD 27th & Welton Light Rail Station, neighborhood coffee shops and restaurants, and only minutes from Downtown Denver and Uptown, the property offers an exceptional blend of urban convenience, historic character, and neighborhood connectivity. The property includes an approximately 2,565-square-foot historic residence with five bedrooms and two bathrooms, currently operating as a successful Airbnb and providing immediate income or the opportunity for owner occupancy. Tucked behind the residence is a rare, private rear
patio, offering an inviting outdoor retreat ideal for entertaining, relaxing, or complementing a live/work lifestyle—an uncommon amenity for a property so close to downtown. Complementing the residence is a separate office duplex totaling approximately 4,000 square feet, comprised of two approximately 2,000-square-foot office suites, one of which is currently leased on a month-to-month basis, providing immediate cash flow while preserving flexibility for future occupancy, repositioning, or redevelopment.
Located within the Clements Historic District, this unique property offers exceptional visibility, walkability, and access to some of Denver’s most desirable dining, entertainment, cultural, and transit amenities. Whether envisioned as an investment, corporate headquarters with supplemental income, creative office campus, live/work environment, boutique hospitality concept, or long-term repositioning opportunity, this one-of-a-kind asset presents remarkable versatility in one of Denver’s most vibrant and historically significant neighborhoods.
- Houzeo last checked: 12 hours ago
- Listing updated: August 24, 2026 at 3:12 pm
- Listing Provided by: Karen Zeile (303) 947-3665 | Kentwood Commercial, Llc (303) 773-3399
- Source: DENVER (RE COLORADO) MLS-CO | MLS#: 6487194

Property Details
Status
Active
Type
Single Family Residence
No. of Stories
-
County
City
Neighborhood
Year Built
1886
HOA Fees
-
Finished Area
2,565 sqft
Lot Size
6,270 sqft lot
Basement Area
- sqft
MLS Name
DENVER (RE COLORADO) MLS
MLS Number
6487194
MLS Status
Active
Days on Market
241

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Location
Facts & Features
Rooms
Bedrooms & bathrooms
Bedrooms: 4
Bathrooms: 2
Bathroom Full
Level: Upper
Bathroom Three Quarter
Level: Main
Bedroom
Level: Main
Bedroom
Level: Upper
Bedroom
Level: Upper
Bedroom
Level: Upper
Interior
Sewer
Public Sewer
Cooling
None
Heating
Hot Water
Construction
Year Built
Year Built: 1886
Home type
Single Family Residence
Roof
Composition
Construction Materials
Brick
Other Features
Subdivision Name
Five Points
Lot Features
Level
Price History
| Date | Event | Price |
|---|---|---|
08/24/2026 Source: #REC6487194 | Price Decreased | $1,000,000 -9.09% $390/sqft |
07/24/2026 Source: | Price Decreased | $1,100,000 -4.35% $429/sqft |
06/24/2026 Source: | Listed for Sale | $1,150,000 $448/sqft |
06/24/2026 Source: | Price Decreased | $1,150,000 -4.17% $448/sqft |
03/27/2026 Source: | Pending | $1,200,000 $468/sqft |
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Five Points Ranks #5 in Denver, CO
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